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Anti-Uroplakin Ia Rabbit pAb (100 μl)
| Reactivity: | R & M,R |
| Applications: | WB & IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Uroplakin Ia rabbit polyclonal |
Gene Name: | Uroplakin-1a |
Synonyms: | Tetraspanin 21, Tspan 21, TSPAN21, UP1A, UPIA, UPK1A, UPKA, uroplakin 1A, Uroplakin Ia |
Immunogen: | Recombinant protein corresponding to Mouse Uroplakin Ia |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Predicted MW. | 29 kDa |
Observed MW. | 29 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Rat | 1: 300-1: 600 | prostate |
IHC | Mouse, Rat | 1: 2000-1: 4000 | bladder |
Background
Uroplakins are a group of urothelial differentiation-related membrane proteins. They are components of the asymmetric unit membrane (AUM), which forms the apical plaques of mammalian urothelium and is believed to play a role in strengthening the urothelial apical surface thus preventing the cells from rupturing during bladder distention . Uroplakin-1a (UPK1A) belongs to the tetraspanin (TM4SF) family. UPK1A plays an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane.
Images
Western blot analysis of Upk1a (GB113288) at dilution of 1: 600 | |
| Immunohistochemistry analysis of paraffin-embedded mouse bladder using Uroplakin Ia (GB113288) at dilution of 1: 4000 |
| Immunohistochemistry analysis of paraffin-embedded rat bladder using Uroplakin Ia (GB113288) at dilution of 1: 4000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
