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| Reactivity: | H,M,R |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | V2R rabbit polyclonal |
Gene Name: | Vasopressin V2 receptor |
Synonyms: | V2R, AVPR V2, Antidiuretic hormone receptor, Renal-type arginine vasopressin receptor, Avpr2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse V2R |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Mouse, Rat | 1: 600-1: 1200 | kidney, lung |
Background
This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism.
Images
| Immunohistochemistry analysis of paraffin-embedded human kidney using AVPR2 (GB112527) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin-embedded rat kidney using AVPR2 (GB112527) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin-embedded mouse lung using AVPR2 (GB112527) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin-embedded rat lung using AVPR2 (GB112527) at dilution of 1: 1200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
