Your shopping cart is empty!
Anti-VPS72 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Vacuolar protein sorting-associated protein 72 homolog |
Synonyms: | Protein YL-1, Transcription factor-like 1, Vps72, Tcfl1, Yl1, transformation suppressor gene YL-1, Vacuolar protein sorting-associated protein 72 homolog |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse VPS72 |
Uniprot ID: | Q62481 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Predicted MW. / Observed MW. | 41 kDa / 60 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 500-1: 1000 | heart, brain, thymus |
IHC/IF | Mouse, Rat | 1: 250-1: 500 | brain |
Background
Vacuolar protein sorting-associated protein 72 homolog (VPS72) is a 364 amino acid subunit of the TRRAP/TIP60 HAT complex. VPS72 has also been identified as a subunit of a novel complex containing SNF2-related helicase SRCAP (SWI2/SNF2-related CBP activator protein). This SRCAP-containing complex is very similar to the S. cerevisiae SWR1 chromatin remodeling complex. The involvement of VPS72 in these complexes has suggested that VPS72 plays multiple roles in chromatin modification and remodeling in cells. VPS72 localizes to the nucleus and is phosphorylated upon DNA damage, most likely by ATM or ATR.
Images
| Western blot analysis of VPS72 (GB111468) at dilution of 1: 500 |
| Immunofluorescence analysis of paraffin embedded mouse brain using VPS72 (GB111468) at dilution of 1: 250 |
|
Immunofluorescence analysis of paraffin embedded rat brain using VPS72 (GB111468) at dilution of 1: 250 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
