Your shopping cart is empty!
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Serine/threonine-protein kinase VRK2 |
Synonyms: | vaccinia related kinase 2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse VRK2 |
Uniprot ID: | Q8BN21 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Endoplasmic reticulum membrane |
Product Usage Information
IHC/IF | Human, Mouse, Rat | 1: 500-1: 2000 | renal carcinoma, liver, kidney, brain |
Background
Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates histone H3. Phosphorylates 'Thr-18' of p53/TP53, and thereby increases its stability and activity. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins.
Images
| Immunohistochemistry analysis of paraffin embedded human renal carcinoma using VRK2 (GB115086) at dilution of 1: 600 |
| Immunohistochemistry analysis of paraffin embedded human kidney using VRK2 (GB115086) at dilution of 1: 600 |
| Immunohistochemistry analysis of paraffin embedded rat brain using VRK2 (GB115086) at dilution of 1: 600 |
| Immunohistochemistry analysis of paraffin embedded mouse brain using VRK2 (GB115086) at dilution of 1: 600 |
| Immunohistochemistry analysis of paraffin embedded mouse liver using VRK2 (GB115086) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
