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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | WD repeat-containing protein 1 |
Synonyms: | Actin interacting protein 1, AIP1, NORI 1, WD repeat containing protein 1, WD repeat domain 1, WDR1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse WDR1 |
Uniprot ID: | O88342 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 66 kDa / 70 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 800-1: 1500 | testis |
Background
Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins . Enhances cofilin-mediated actin severing . Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions . Involved in myocardium sarcomere organization. Required for cardiomyocyte growth at the postnatal and maintenance at the adult stage . Involved in neutrophil actin dynamics and migration. Involved in megakaryocyte maturation and platelet shedding . Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension .
Images
| Western blot analysis of WDR1 (GB114660) at dilution of 1: 1500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
