Your shopping cart is empty!
| Reactivity: | H,R,M |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | XIAP rabbit polyclonal antibody |
Gene Name: | E3 ubiquitin-protein ligase XIAP |
Synonyms: | Xiap, XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3, X-linked inhibitor of apoptosis |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse XIAP |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 250-1: 1500 | colon cancer, corpus striatum, lung, stomach |
Background
X-linked inhibitor of apoptosis protein (XIAP) is a protein that stops apoptotic cell death. XIAP is a member of the inhibitor of apoptosis family of proteins (IAP). XIAP stops apoptotic cell death that is induced either by viral infection or by overproduction of caspases. Caspases are the enzymes primarily responsible for cell death. XIAP binds to and inhibits caspase 3, 7 and 9. The BIR2 domain of XIAP inhibits caspase 3 and 7, while BIR3 binds to and inhibits caspase 9.
Images
|
|
Immunohistochemistry of paraffin embedded human colon cancer using XTAP (GB11888) at dilution of 1:800 (200x lens) |
 | Immunohistochemistry of paraffin embedded rat stomach using XTAP (GB11888) at dilution of 1:800 (300x lens) |
 | Immunofluorescence of paraffin embedded mouse corpus striatum using XIAP (GB11888) at dilution of 1:500 (200x lens) |
 |
Immunofluorescence of paraffin embedded rat lung using XIAP (GB11888) at dilution of 1:500 (300x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
