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| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | YAP1 rabbit polyclonal antibody |
Gene Name: | Transcriptional coactivator YAP1 |
Synonyms: | YAP1, COB1, YAP, YAP2, YAP65, YKI, Yes associated protein 1, Yap |
Immunogen: | Recombinant protein corresponding to Mouse YAP1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 52 kDa |
Observed MW. | 65 kDa |
Uniprot ID: | P46937, P46938, Q2EJA0 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | heart, kidney |
Background
YAP1 is a transcriptional co-activator and its proliferative and oncogenic activity is driven by its association with the TEAD family of transcription factors, which up-regulate genes that promote cell growth and inhibit apoptosis. Several other functional partners of YAP1 were identified, including RUNX, SMADs, p73, ErbB4,TP53BP, LATS1/2, PTPN14, AMOTs, and ZO1/2. YAP1 and its close paralog, TAZ (WWTR1), are the main effectors of the Hippo tumor suppressor pathway.When the pathway is activated, YAP1 and TAZ are phosphorylated on a serine residue and sequestered in the cytoplasm by 14-3-3 proteins. When the Hippo pathway is not activated, YAP1/TAZ enter the nucleus and regulate gene expression.
Images
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Western blot analysis of YAP (GB11542) at dilution of 1: 500
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Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
