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Anti-Zfp281/ZNF281 Rabbit pAb (100 μl)
| Reactivity: | M,R & M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Zinc finger protein 281 |
Synonyms: | |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse ZNF281 |
Uniprot ID: | Q99LI5 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 97 kDa / 97/117 kDa |
Product Usage Information
WB | Mouse | 1: 800-1: 1500 | A20 |
Background
Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs. Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes.
Images
| Western blot analysis of ZNF281 (GB115120) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
