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Anti-alpha Actinin Rabbit pAb (100 μl)
| Reactivity: | M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | alpha Actinin rabbit polyclonal antibody |
Gene Name: | Alpha-actinin-1 |
Synonyms: | Alpha-actinin cytoskeletal isoform, F-actin cross-linking protein, actinin, Non-muscle alpha-actinin-1, ACTN1, actinin 1 smooth muscle, Actn1a, BDPLT15, I79_004057 |
Immunogen: | Recombinant protein corresponding to Mouse α-actinin1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 103 kDa |
Observed MW. | 103 kDa |
Uniprot ID: | Q7TPR4, P12814, Q9Z1P2 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 2000-1: 4000 | lung, stomach, colon, hysteromyoma |
Background
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found alongmicrofilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene.
Images
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Western blot analysis of a-Actinin (GB11230) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
