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Anti-c-Myb Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | c-Myb rabbit polyclonal antibody |
Gene Name: | Transcriptional activator Myb |
Synonyms: | Proto-oncogene c-Myb, Myb, MYB proto-oncogene transcription factor, v-myb avian myeloblastosis viral oncogene homolog, Cmyb |
Immunogen: | Recombinant protein corresponding to Mouse c-Myb |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 71 kDa |
Observed MW. | 80 kDa |
Uniprot ID: | P10242, P06876 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | spleen, kidney, colon |
Background
The MYB protein is a transcription factor that plays a key role in regulating the proliferation/differentiation of progenitor cells in bone marrow, colonic crypts, and neurogenic niches . It is involved in the regulation of epithelial-to-mesenchymal transition (EMT) and invasion in neuroblastoma, colon carcinoma, and embryonic kidney cells through the upregulation of the transcription repressor Slug . It also a DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3', and plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
Images
| Western blot analysis of cMYB (GB112317) at dilution of 1: 500 |
| Western blot analysis of cMYB (GB112317) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
