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| Reactivity: | H,M,R |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | c-Myc rabbit polyclonal |
| Gene Name: |
Myc proto-oncogene protein |
|
Synonyms: |
Myc proto-oncogene protein, Class E basic helix-loop-helix protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription factor p64, MYC, BHLHE39 |
| Immunogen: |
KLH conjugated Synthetic peptide corresponding to human Myc |
| Isotype: | IgG |
| Purity: | Affinity purification |
| Subcellular location: |
Nucleus |
| Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Mouse, Rat | 1:100-1:200 | Liver cancer, breast cancer,lung |
Background
C-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Myc proteins are nuclear proteins with relatively short half lives. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. The presence of three sequence motifs in the c-Myc COOH terminus, including the leucine zipper, the helix-loop-helix and a basic region provided initial evidence for a sequence-specific binding function.
Images
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Immunohistochemistry analysis of paraffin-embedded human liver cancer using c-Myc (GB13076) at dilution of 1:100 |
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Immunohistochemistry analysis of paraffin-embedded human breast cancer using c-Myc (GB13076) at dilution of 1:100 |
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Immunohistochemistry analysis of paraffin-embedded mouse lung using c-Myc (GB13076) at dilution of 1:100 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
