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Anti-p115-RhoGEF Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | p115-RhoGEF rabbit polyclonal antibody |
Gene Name: | Rho guanine nucleotide exchange factor 1 |
Synonyms: | Lbc's second cousin, Lymphoid blast crisis-like 2, Arhgef1, Lbcl2, Lsc, 115 kDa guanine nucleotide exchange factor, GEF1, Lsc homolog |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human p115-RhoGEF |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 103 kDa |
Observed MW. | 80 kDa |
Uniprot ID: | Q92888 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human | 1: 1000-1: 2000 | HeLa, 293T, A549, McF-7 |
Background
This gene seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.
Images
 | Western blot analysis of ARHGEF1 (GB112380) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
