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| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | uPA rabbit polyclonal antibody |
Gene Name: | Urokinase-type plasminogen activator |
Synonyms: | U-plasminogen activator, Plau, ATF, URK, uPA, Urinary, Urokinase |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse uPA |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 48 kDa |
Observed MW. | 48 kDa |
Uniprot ID: | P00749, P06869 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse | 1: 500-1: 1000 | prostate |
Background
PLAU, a member of the peptidase family S1, is a potent plasminogen activator and is clinically used for therapy of thrombolytic disorders.
PLAU specifically cleaves the Arg-|-Val bond in plasminogen to form plasmin uPA is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium . The protein is found in high and low molecular mass forms. The single chain molecule is processed into a disulfide-linked two-chain molecule.Each consists of two chains, A and B. The high molecular mass form contains a long chain A. Cleavage occurs after residue 155 in the low molecular mass form to yield a short A1 chain. The protein is used in Pulmonary Embolism (PE) to initiates fibrinolysis. Structurally, PLAU contains 1 EGF-like domain and 1 kringle domain.
Images
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Western blot analysis of UPA (GB11958) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
