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| Reactivity: | Human |
| Applications: | FCM |
| Host Species: | Mouse |
| Isotype: | Mouse IgG2b, κ |
| Clonality: | Monoclonal |
| Conjugation: | Unconjugated |
| Synonyms: | B7-H1, PD-L1, Programmed cell death ligand 1, B7 homolog 1, B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1 |
| Background: | CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells. |
| Gene ID: | 29126 |
| SwissProt: | Q9NZQ7 |
| Concentration: | 0.5 mg/mL |
| Buffer: | PBS with 0.05% Proclin300 |
| Storage: | Store at 2~8°C. Do not freeze. |
| Documents: | Please contact us to request the manual |
