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| Reactivity: | H,M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | RCC1 rabbit polyclonal antibody |
Gene Name: | Regulator of chromosome condensation |
Synonyms: | Chromosome condensation protein 1, Rcc1, Chc1 |
Immunogen: | Recombinant protein corresponding to Mouse RCC1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Predicted MW. | 45 kDa |
Observed MW. | 50 kDa |
Uniprot ID: | P18754, Q8VE37 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain, testis, small intestine |
IHC/IF | Mouse, Rat | 1: 1000-1: 4000 | brain, small intestine |
Background
CHC1, also named as RCC1, promotes the exchange of ran-bound gdp by gtp. It is involved in the regulation of onset of chromosome condensation in the S-phase. Phosphorylation of RCC1 on serines located in or near its nuclear localization signal activates RCC1 to generate RanGTP on mitotic chromosomes, which is required for spindle assembly and chromosome segregation.
Images
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Western blot analysis of RCC1 (GB111428) at dilution of 1: 500 |
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Immunohistochemistry of paraffin embedded mouse small intestine using RCC1 (GB111428) at dilution of 1: 2000 (300x lens) |
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Immunohistochemistry of paraffin embedded rat brain using RCC1 (GB111428) at dilution of 1: 2000 (200x lens) |
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Immunohistochemistry of paraffin embedded rat small intestine using RCC1 (GB111428) at dilution of 1: 2000 (300x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
