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Anti-RECQL5 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | ATP-dependent DNA helicase Q5 |
Synonyms: | ATP dependent DNA helicase Q5, DNA helicase, RecQ like type 5, RecQ protein like 5, RECQ5, RECQL5 |
Immunogen: | Recombinant protein corresponding to Mouse RECQL5 |
Uniprot ID: | Q8VID5 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Product Usage Information
IHC/IF | Mouse, Rat | 1: 1500-1: 3000 | heart, kidney |
Background
DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination (By similarity).
Images
| Immunohistochemistry analysis of paraffin embedded mouse heart using RECQL5 (GB114230) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin embedded mouse kidney using RECQL5 (GB114230) at dilution of 1: 3000 |
| Immunofluorescence analysis of paraffin embedded rat heart using RECQL5 (GB114230) at dilution of 1: 1500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
