Reactivity: | H |
Applications: | WB |
Host Species: | Rabbit |
Clonality: | Polyclonal |
Gene Name: | E3 ubiquitin-protein ligase MGRN1 |
Synonyms: | KIAA0544, mahogunin, ring finger 1, MGRN1, RING finger protein 156, RNF156 |
Immunogen: | Recombinant protein corresponding to Mouse RNF156 |
Uniprot ID: | Q9D074 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 58 kDa / 65 kDa |
Product Usage Information
WB | Human | 1: 300-1: 500 | Jurkat |
Background
E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination (By similarity). Acts also as a negative regulator of hedgehog signaling.
Images
Western blot analysis of RNF156 (GB114459) at dilution of 1: 500 |
Storage
Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |