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Anti-RNase L Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | 2-5A-dependent ribonuclease |
Synonyms: | 2 5A dependent ribonuclease, 2 5A dependent RNase, PRCA1, Ribonuclease 4, Ribonuclease L, RNase L, RNASEL, RNS4 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse RNase L |
Uniprot ID: | Q05921 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 83 kDa / 80 kDa |
Product Usage Information
WB | Human | 1: 400-1: 800 | 293T |
Background
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances.
Images
| Western blot analysis of RNASEL (GB114663) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
