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| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Rb rabbit polyclonal antibody |
Gene Name: | Retinoblastoma-associated protein |
Synonyms: | p110-RB1, pRb, Rb, pp105, Rb1, Rb-1, p105-Rb, OSRC, Prepro retinoblastoma associated protein |
Immunogen: | Recombinant protein corresponding to Mouse Rb |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 105 kDa |
Observed MW. | 105 kDa |
Uniprot ID: | P13405 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse | 1: 300-1: 600 | kidney |
Background
RB1, also named as pp110, pRb and p105 Rb, belongs to the retinoblastoma protein (RB) family. It is a key regulator of entry into cell division that acts as a tumor suppressor. RB1 acts as a transcription repressor of E2F1 target genes.Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human RB1.
Images
 | Western blot analysis of Rb (GB112449) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
