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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SARM rabbit polyclonal antibody |
Gene Name: | NAD(+) hydrolase SARM1 |
Synonyms: | NADase SARM1, NADP(+) hydrolase SARM1, Sterile alpha and TIR motif-containing protein 1, Sarm1, Kiaa0524, MyD88-5, SAM domain-containing protein 2, Tir-1 homolog |
Immunogen: | Recombinant protein corresponding to Mouse SARM |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 80 kDa |
Observed MW. | 73 kDa |
Uniprot ID: | Q6SZW1, Q6PDS3 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | heart, brain, liver |
Background
SARM, also known as SAMD2, SARM1 or KIAA0524, is a 724 amino acid protein that localizes to the cytoplasm and contains one TIR domain and two sterile alpha motif (SAM) domains. Expressed predominately in liver and kidney and present at lower levels in placenta, SARM interacts with TICAM-1 and, via this interaction, blocks the transcriptional activation activity of TICAM-1 and functions as a negative regulator of Toll-like receptor signaling. Additionally, SARM is thought to be involved in innate immune responses and may also play a role in the negative regulation of NFⅹB activation. SARM exists as two alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 17.
Images
| Western blot analysis of SARM1 (GB112070) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
