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| Reactivity: | H & H,M |
| Applications: | WB & ICC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Protein SCO2 homolog, mitochondrial |
Synonyms: | SCO1L, SCO2 |
Immunogen: | Recombinant protein corresponding to Mouse SCO2 |
Uniprot ID: | Q8VCL2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Mitochondrion |
Predicted MW. / Observed MW. | 29 kDa / 29 kDa |
Product Usage Information
WB | Human | 1: 700-1: 1400 | HEK 293, PC-3 |
ICC/IF | Human, Mouse | 1: 50-1: 200 | HeLa, NIH-3T3 |
Background
Human SCO2 is a mitochondrial membrane-bound protein involved in copper supply for the assembly of cytochrome c oxidase in eukaryotes.It is involved in the maintenance of cell copper homeostasis or, limited to HSco2, as a downstream mediator of the Warburg effect, as its expression is regulated by p53(PMID:17850752).This protein belongs to the SCO1/2 family and defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC).
Images
 | Western blot analysis of SCO2 (GB113999) at dilution of 1: 1000 |
| Immunocytochemistry analysis of 4% paraformaldehyde-fixed HeLa cells using SCO2(GB113999) at dilution of 1: 50-1: 200 |
| Immunocytochemistry analysis of 4% paraformaldehyde-fixed NIH-3T3 cells using SCO2(GB113999) at dilution of 1: 50-1: 200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
