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| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SFT rabbit polyclonal antibody |
Gene Name: | Ubiquitin-conjugating enzyme E2 D1 |
Synonyms: | Stimulator of Fe transport, UBC4/5, UBCH5A, Ube2d1, Ubiquitin carrier protein, Ubiquitin-protein ligase D1, SFT, UbcH5 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse SFT |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 17 kDa |
Observed MW. | 17 kDa |
Uniprot ID: | P61080 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse | 1: 500-1: 1500 | kidney |
Background
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene.
Images
 | Western blot analysis of UBE2D1 (GB113907) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
