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| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SMAD6 rabbit polyclonal antibody |
Gene Name: | Mothers against decapentaplegic homolog 6 |
Synonyms: | SMAD6, AOVD2, HsT17432, MADH6, MADH7, SMAD family member 6 |
Immunogen: | Recombinant protein corresponding to Mouse SMAD6 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: | O35182 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 250-1: 1500 | brain, breast cancer, colon, heart, liver cancer, lung, testis |
Background
SMAD family member 6, also known as SMAD6, belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members SMAD6 is involved in cell signalling. It acts as a regulator of TGFβ family (such as bone morphogenetic proteins) activity by competing with SMAD4 and preventing the transcription of SMAD4's gene products. There are two known isoforms of this protein.
Images
 | Immunohistochemistry of paraffin embedded mouse brain using smad62024 (GB11654) at dilution of 1:1000 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse brain using smad62024 (GB11654) at dilution of 1:1500 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse heart using smad62024 (GB11654) at dilution of 1:1000 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse lung using smad62024 (GB11654) at dilution of 1:1000 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat brain using smad62024 (GB11654) at dilution of 1:1000 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat brain using smad62024 (GB11654) at dilution of 1:1500 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat heart using smad62024 (GB11654) at dilution of 1:1000 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat lung using smad62024 (GB11654) at dilution of 1:1000 (400x lens) |
 | Immunofluorescence of paraffin embedded human breast cancer using smad62024 (GB11654) at dilution of 1:1000 (400x lens) |
 | Immunofluorescence of paraffin embedded human liver cancer using smad62024 (GB11654) at dilution of 1:1000 (400x lens) |
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Immunofluorescence of paraffin embedded mouse testis using smad62024 (GB11654) at dilution of 1:1000 (300x lens) |
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Immunofluorescence of paraffin embedded mouse brain using smad62024 (GB11654) at dilution of 1:1000 (400x lens) |
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Immunofluorescence of paraffin embedded mouse colon using smad62024 (GB11654) at dilution of 1:1000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
