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Anti-SREBP1 Rabbit pAb (100 μl)
| Reactivity: | H & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SREBP1 rabbit polyclonal |
Gene Name: | Sterol regulatory element-binding protein 1 |
Synonyms: | bHLHd1, SREBF1, SREBP-1, SREBP 1c, SREBP1, Class D basic helix-loop-helix protein 1, Transcription factor SREBF1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human SREBP1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Predicted MW. | 122 kDa |
Observed MW. | 122/54 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human | 1: 500-1: 1000 | HepG2, A549, MCF-7 |
IHC/IF | Human | 1: 500-1: 1000 | liver, liver cancer, adrenocortical adenoma |
Background
SREBF1, also named as BHLHD1 and SREBP1, contains one basic helix-loop-helix (bHLH) domain and belongs to the SREBP family. It is a transcriptional activator required for lipid homeostasis. The SREBPs are synthesized as precursors anchored to endoplasmic reticulum (ER) membranes and complexed with SCAP. When the cellular cholesterol level is low, SREBP-SCAP complexes move to the Golgi apparatus, where SREBPs undergo a two-step proteolytic processing, leading to the release of the mature form, an N-terminal fragment, i.e, basic helix-loop-helix leucine zipper transcription factor.
Images
| Western blot analysis of SREBP1 (GB113804) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded human adrenocortical adenoma using SREBP1 (GB113804) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded human liver cancer using SREBP1 (GB113804) at dilution of 1: 1000 |
 | Immunohistochemistry analysis of paraffin-embedded human liver using SREBP1 (GB113804) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
