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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | DENN domain-containing protein 2B |
Synonyms: | DENND2B, HeLa tumor suppression 1, HTS1, p126, ST5 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse ST5 |
Uniprot ID: | Q924W7 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 127 kDa / 127 kDa |
Product Usage Information
WB | Human | 1: 300-1: 600 | U-251MG, HeLa, A-431 |
Background
[Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane. ; [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. ; [Isoform 3]: May block ERK2 activation stimulated by ABL1. May alter cell morphology and cell growth.
Images
| Western blot analysis of ST5 (GB114632) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
