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| Reactivity: | R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | STAT3 rabbit polyclonal antibody |
Gene Name: | Signal transducer and activator of transcription 3 |
Synonyms: | ADMIO, APRF, HIES, ADMIO1, Acute-phase response factor, STAT3 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse STAT3 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 88 kDa |
Observed MW. | 90 kDa |
Uniprot ID: | P42227, P40763, P52631 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain, lung |
Background
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Acts as a regulator of inflammatory response by regulating differentiation of naive CD4+ T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (By similarity).
Images
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Western blot analysis of STAT3 (GB11176) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
