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| Reactivity: | H,M & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Synaptotagmin-1 |
Synonyms: | Synaptotagmin I, SytI, p65, DKFZp781D2042, FLJ42519, SVP65, Syt2 |
Immunogen: | Recombinant protein corresponding to Mouse SYT1 |
Uniprot ID: | P46096 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell Membrane |
Predicted MW. / Observed MW. | 47 kDa / 60 kDa |
Images
WB | Mouse, Rat | 1: 500-1: 1000 | brain, cerebral cortex, hippocampus |
IHC/IF | Human | 1: 1000-1: 4000 | lung cancer |
Background
This protein calcium sensor that participates in triggering neurotransmitter release at the synapse . May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca2+-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported.
Images
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Western blot analysis of syt1 (GB111130) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin embedded human lung cancer using syt1 (GB111130) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
