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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SYT1 rabbit polyclonal antibody |
Gene Name: | Synaptotagmin-1 |
Synonyms: | Synaptotagmin I, SytI, p65, DKFZp781D2042, FLJ42519, SVP65, Syt2 |
Immunogen: | Recombinant protein corresponding to Mouse SYT1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 47 kDa |
Observed MW. | 60 kDa |
Uniprot ID: | P46096, P21707 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 500-1: 1000 | brain, cerebral cortex |
Background
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter release at the synapse. Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
Images
| Western blot analysis of SYT1 (GB112106) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
