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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Synaptotagmin-7 |
Synonyms: | SYT VII, SYT7, Synatotagmin 7, Synaptotagmin VII, IPCA7, PCANAP7, IPCA-7 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Synaptotagmin VII |
Uniprot ID: | Q9R0N7 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 45 kDa / 45 kDa |
Product Usage Information
WB | Human | 1: 1000-1: 2000 | HT-29 |
Background
Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis. SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins . Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair. Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages .
Images
| Western blot analysis of SYT7 (GB114712) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
