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Anti-Seladin 1 Rabbit pAb (100 μl)
| Reactivity: | H & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Seladin 1 rabbit polyclonal antibody |
Gene Name: | Delta(24)-sterol reductase |
Synonyms: | 24-dehydrocholesterol reductase, 3-beta-hydroxysterol Delta-24-reductase, Diminuto/dwarf1 homolog, Seladin-1, DHCR24, KIAA0018 |
Immunogen: | Recombinant protein corresponding to Mouse Seladin 1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Predicted MW. | 60 kDa |
Observed MW. | 60 kDa |
Uniprot ID: | Q15392, Q8VCH6, Q5BQE6 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human | 1: 500-1: 1000 | HT-29, HeLa |
IHC/IF | Mouse, Rat | 1: 500-1: 3000 | colon, duodenum, liver, lung, small intestine |
Background
The Seladin 1 encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.Missense mutations in this gene have been associated with desmosterolosis.
Images
| Western blot analysis of Dhcr24 (GB112463) at dilution of 1: 500 |
| Immunohistochemistry of paraffin embedded mouse duodenum using Dhcr24 (GB112463) at dilution of 1: 650 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse liver using Dhcr24 (GB112463) at dilution of 1: 1300 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse lung using Dhcr24 (GB112463) at dilution of 1: 1300 (400x lens) |
| Immunohistochemistry of paraffin embedded rat colon using Dhcr24 (GB112463) at dilution of 1: 650 (400x lens) |
| Immunohistochemistry of paraffin embedded rat liver using Dhcr24 (GB112463) at dilution of 1: 1300 (400x lens) |
| Immunohistochemistry of paraffin embedded rat lung using Dhcr24 (GB112463) at dilution of 1: 1300 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat small intestine using Dhcr24 (GB112463) at dilution of 1: 650 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse duodenum using Dhcr24 (GB112463) at dilution of 1: 650 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse lung using Dhcr24 (GB112463) at dilution of 1: 650 (400x lens) |
| Immunofluorescence of paraffin embedded rat duodenum using Dhcr24 (GB112463) at dilution of 1: 650 (400x lens) |
| Immunofluorescence of paraffin embedded rat lung using Dhcr24 (GB112463) at dilution of 1: 650 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
