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Anti-SerpinB2/PAI-2 Rabbit pAb (100 μl)
| Reactivity: | H,M & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Plasminogen activator inhibitor 2, macrophage |
Synonyms: | PAI-2, Serpin B2, Serpinb2, Pai2, Planh2, Monocyte Arginine-serpin, Urokinase inhibitor |
Immunogen: | Recombinant protein corresponding to Mouse SerpinB2/PAI-2 |
Uniprot ID: | P12388 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Secreted |
Predicted MW. / Observed MW. | 46 kDa / 42 kDa |
Product Usage Information
WB | Human, Mouse | 1: 500-1: 1000 | skin |
IHC/IF | Human, Mouse, Rat | 1: 600-1: 1200 | Hodgkin's lymphoma, skin |
Background
SerpinB2 is a serine proteinase inhibitor of the ovalbumin like B clade of serpins. It was first discovered in the placenta, and given the name PAI-2 because of the ability to inhibit urokinase plasminogen activator (u-PA) at low micromolar efficiency. SerpinB2 also inhibits tissue plasminogen activator (t-PA), but with micromolar efficiency, and PAI-1 is much more efficient that SerpinB2 on both forms of plasminogen activator. The structure of PAI-2 is not terribly similar to PAI-1, however, which is an E clade serpin.
Images
| Western blot analysis of PAI-2 (GB112219) at dilution of 1: 1000 |
| Immunofluorescence analysis of paraffin embedded human Hodgkin's lymphoma using PAI2 (GB112219) at dilution of 1: 600 |
| Immunofluorescence analysis of paraffin embedded mouse skin using PAI2 (GB112219) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
