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Anti-SerpinB4/SCCA-2 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SerpinB4/SCCA-2 rabbit polyclonal |
Gene Name: | Serpin B4 |
Synonyms: | Leupin, Peptidase inhibitor 11, PI-11, Squamous cell carcinoma antigen 2, SCCA-2, SERPINB4, PI11, SCCA2 |
Immunogen: | Recombinant protein corresponding to Human SerpinB4 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human | 1: 1800-1: 3600 | lung cancer, esophageal cancer |
Background
The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation.
Images
| Immunohistochemistry analysis of paraffin-embedded human lung cancer using SerpinB4 (GB112723) at dilution of 1: 3600 |
| Immunohistochemistry analysis of paraffin-embedded human esophageal cancer using SerpinB4 (GB112723) at dilution of 1: 3600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
