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Anti-ABCB11/BSEP Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ABCB11/BSEP rabbit polyclonal antibody |
Gene Name: | Bile salt export pump |
Synonyms: | ABC16, ABCB11, Bile salt export pump, BRIC2, BSEP, PFIC 2, PFIC2, PGY4, SPGP |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse ABCB11/BSEP |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Endosome, Cell membrane |
Uniprot ID: | Q9QY30 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 300-1: 1000 | liver |
Background
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.
Images
| Immunohistochemistry of paraffin embedded mouse liver using ABCB11 (GB113909) at dilution of 1: 500 (400x lens) |
| Immunohistochemistry of paraffin embedded rat liver using ABCB11 (GB113909) at dilution of 1: 500 (400x lens) |
| Immunofluorescence of paraffin embedded embedded mouse liver using ABCB11 (GB113909) at dilution of 1: 300 (400x lens) |
| Immunofluorescence of paraffin embedded embedded rat liver using ABCB11 (GB113909) at dilution of 1: 300 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
