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Anti-ABCB4 Rabbit pAb (100 μl)
| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Phosphatidylcholine translocator ABCB4 |
Synonyms: | ABC21, ABCB4, GBD1, MDR2, MDR2/3, MDR3, Multidrug resistance protein 3, P glycoprotein 3, PFIC 3, PGY3 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse ABCB4 |
Uniprot ID: | P21440 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 140 kDa / 160 kDa |
Product Usage Information
WB | Mouse | 1: 300-1: 600 | spleen, lung |
Background
Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi between hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts . Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes .
Images
| Western blot analysis of ABCB4 (GB114613) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
