Reactivity: | M,R |
Applications: | WB |
Host Species: | Rabbit |
Clonality: | Polyclonal |
Gene Name: | 3-ketoacyl-CoA thiolase, mitochondrial |
Synonyms: | ACAA2, Acetyl CoA acyltransferase, Beta ketothiolase, DSAEC, T1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse ACAA2 |
Uniprot ID: | Q8BWT1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 42 kDa / 42 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 1500-1: 3000 | liver, kidney, lung |
Background
In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies. Also displays hydrolase activity on various fatty acyl-CoAs. Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation.
Images
Western blot analysis of ACAA2 (GB114720) at dilution of 1: 1500 |
Storage
Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |