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Anti-AIMP2/p38 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 |
Synonyms: | AIMP2, JTV1, JTV1 gene, P38, PRO0992, Protein JTV 1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse AIMP2/p38 |
Uniprot ID: | Q8R010 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Product Usage Information
IHC/IF | Human | 1: 400-1: 800 | endometrial carcinoma, endometrial cancer, kidney |
Background
Required for assembly and stability of the aminoacyl-tRNA synthase complex . Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation . Blocks MDM2-mediated ubiquitination and degradation of p53/TP53 . Functions as a proapoptotic factor .
Images
| Immunohistochemistry analysis of paraffin embedded human kidney using AIMP2 (GB114722) at dilution of 1: 400 |
| Immunohistochemistry analysis of paraffin embedded human endometrial carcinoma using AIMP2 (GB114722) at dilution of 1: 400 |
| Immunofluorescence of paraffin embedded human endometrial cancer using AIMP2 (GB114722) at dilution of 1: 400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
