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Anti-ARPC5/p16 ARC Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Actin-related protein 2/3 complex subunit 5 |
Synonyms: | ARC16, ARPC5, p16 Arc |
Immunogen: | Recombinant protein corresponding to Mouse ARPC5 |
Uniprot ID: | Q9CPW4 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Cytoskeleton, Cell projection, Nucleus |
Predicted MW. / Observed MW. | 16 kDa / 17 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 300-1: 500 | spleen, brain, thymus |
IHC/IF | Human | 1: 900-1: 1800 | lung cancer, colon cancer |
Background
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Images
| Western blot analysis of ARPC5 (GB114419) at dilution of 1: 500 |
| Immunohistochemistry analysis of paraffin embedded human lung cancer using ARPC5 (GB114419) at dilution of 1: 900 |
| Immunofluorescence analysis of paraffin embedded human colon cancer using ARPC5 (GB114419) at dilution of 1: 900 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
