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Recombinant Anti-Amyloid beta 40 Mouse mAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Amyloid-beta precursor protein |
Synonyms: | ABPP, APP, N-APP, Soluble APP-alpha, S-APP-alpha, C99, APP-C99, Abeta42, Abeta40, Beta-APP40, C83, APP-C59, Amyloid intracellular domain 59, APP-C57, Gamma-CTF(50), C31, App, Aβ40, Aβ42, A beta 40,beta Amyloid 40 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Amyloid beta 40 |
Uniprot ID: | P12023 |
Isotype: | IgG1 |
Purity: | Affinity purification |
Subcellular location: | Cell Membrane, Cytoplasm |
Product Usage Information
Applications | Species | Dilution | Positive Tissue |
IHC/IF | Human, Mouse, Rat | 1: 500-1: 1000 | brain |
Background
Most of autosomal dominant familial AD can be attributed to mutations in one of three genes: those encoding amyloid precursor protein (APP) and presenilins 1 and 2 Most mutations in the APP and presenilin genes increase the production of a small protein called Aβ42, which is the main component of senile plaques. Some of the mutations merely alter the ratio between Aβ42 and the other major forms—particularly Aβ40—without increasing Aβ42 levels.
Images
| IHC analysis of Amyloid beta 40(GB151197). Sample: Mouse brain, 4% PFA (G1101) 12-24h. Antigen retrieval: TE buffer (pH9.0)(G1203), 98°C 20min. Primary antibody: 1: 500, 4°C overnight. Secondary antibody: HRP conjugated Goat Anti-Mouse lgG (H+L) (GB23301), 1: 200, RT, 1h. |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.15% ProClin300, 100 μg/mL BSA and 50% glycerol. |
