Reactivity: | H & H,M |
Applications: | IHC/IF & ICC/IF |
Host Species: | Rabbit |
Clonality: | Polyclonal |
Gene Name: | Aquaporin-4 |
Synonyms: | AQP4, Aquaporin 4, HMIWC2, MIWC, WCH4, Aquaporin type 4, Mercurial-insensitive water channel, aquaporin 4 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Rat Aquaporin 4 |
Uniprot ID: | P47863 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Membrane |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Rat | 1: 500-1: 2000 | brain, hippocampus |
IF | Rat | 1: 500-1: 1000 | brain, hippocampus |
Background
Aquaporin-4, also known as AQP4, is a water channel protein, belonging to the aquaporin family of integral membrane proteins that conduct water through the cell membrane. In the CNS, AQP4 is the most prevalent aquaporin channel, specifically located at the perimicrovessel astrocyte foot processes, glia limitans, and ependyma. Aquaporin-4’s overall function is to provide fast water transportation as well as maintain homeostatic balance within the central nervous system. Other systems are also regulated by AQP4.
Images
Immunohistochemistry analysis of paraffin-embedded rat hippocampus using Aquaporin 4 (GB11311-1) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded rat brain using Aquaporin 4 (GB11311-1) at dilution of 1: 1000 |
Storage
Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |