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Anti-Axin 1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Axin 1 rabbit polyclonal antibody |
Gene Name: | Axin-1 |
Synonyms: | Axin1, AXIN1, AXIN, PPP1R49, Axin 1, Axis inhibition protein 1, Axis Inhibitor 1, Protein phosphatase 1 regulatory subunit 49, Protein Fused, PPP1R49 |
Immunogen: | Recombinant protein corresponding to Human Axin 1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 96 kDa |
Observed MW. | 110 kDa |
Uniprot ID: | O15169, O35625, O70239 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | lung |
Background
Axin-1 encoded by the AXIN1 gene in human is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. This protein interacts with adenomatosis polyposis coli, catenin (cadherin-associated protein) beta 1, glycogen synthase kinase 3 beta, protein phosphatase 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medulloblastomas.
Images
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Western blot analysis of Axin1 (GB11729) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |