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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CD10 rabbit polyclonal antibody |
Gene Name: | Neprilysin |
Synonyms: | Atriopeptidase, Enkephalinase, SFE, CD10, Neutral endopeptidase 24.11, NEP, Neutral endopeptidase, Skin fibroblast elastase, Mme |
Immunogen: | Recombinant protein corresponding to Mouse CD10 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 86 kDa |
Observed MW. | 100 kDa |
Uniprot ID: | Q61391, P07861 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | kidney, prostate |
Background
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
Images
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Western blot analysis of CD10 (GB111120) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |