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Anti-CD177 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | CD177 antigen |
Synonyms: | CD177, HNA-2a, HNA2A, NB1, NB1 GP, PRV-1, PRV1, CD177 molecule |
Immunogen: | Recombinant protein corresponding to Human Cd177 |
Uniprot ID: | Q8N6Q3 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Secreted |
Product Usage Information
IHC/IF | Human | 1: 250-1: 500 | colon cancer, gastric carcinoma |
Background
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis.
Images
| Immunohistochemistry analysis of paraffin embedded human colon cancer using CD177 (GB115051) at dilution of 1: 500 |
| Immunohistochemistry analysis of paraffin embedded human gastric carcinoma using CD177 (GB115051) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
