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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CDK2 rabbit polyclonal |
Protein full name | Cyclin-dependent kinase 2 |
Synonyms: | Cell division protein kinase 2, p33 protein kinase, CDK2, CDKN2, CDC28, CDC2A, Cdc2 related protein kinase, p33(CDK2), MPF |
Immunogen: | KLH conjugated Synthetic peptide corresponding to human CDK2 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 34 kDa |
Observed MW. | 34 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse,Rat | 1:500-1:1000 | Lymph node, spleen, stomach |
Background
This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, also known as Cdk1 in humans. It is a catalytic subunit of the cyclin-dependent kinase complex, whose activity is restricted to the G1-S phase of the cell cycle, and is essential[citation needed] for the G1/S transition. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin E or A. Cyclin E binds G1 phase Cdk2, which is required for the transition from G1 to S phase while binding with Cyclin A is required to progress through the S phase. Its activity is also regulated by phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.
Images
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All lanes are mouse mixed tissue lysate Western blot analysis of CDK2 (GB13237) at dilution of 1: 1000. |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |