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Recombinant Anti-CEACAM1 Rabbit mAb (100 μl)
| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Monoclonal |
| Gene Name: | Carcinoembryonic antigen-related cell adhesion molecule 1 |
Synonyms: | Biliary glycoprotein 1, BGP-1, Biliary glycoprotein D, MHVR1, Murine hepatitis virus receptor, MHV-R, CD66a, Ceacam1, Bgp, Bgp1 |
Immunogen: | Recombinant protein corresponding to Mouse CEACAM1 |
Uniprot ID: | P13688 |
Isotype: | lgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Product Usage Information
IHC/IF | Human | 1: 500-1: 1000 | colon, colon cancer |
Background
Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis. Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils. Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70. Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2.
Images
| Immunohistochemistry analysis of paraffin embedded human colon using CEACAM1 (GB152293) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human colon cancer using CEACAM1 (GB152293) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
