Reactivity: | M,R |
Applications: | IHC |
Host Species: | Rabbit |
Clonality: | Polyclonal |
Full Name: | CHST8 rabbit polyclonal |
Gene Name: | Carbohydrate sulfotransferase 8 |
Synonyms: | CHST8, GalNAc 4 O sulfotransferase 1, GalNAc 4 ST1, GalNAc4ST, GALNAC4ST1, N-acetylgalactosamine-4-O-sulfotransferase 1 |
Immunogen: | Recombinant protein corresponding to Mouse CHST8 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Golgi apparatus |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 1500-1: 3000 | pituitary |
Background
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene.
Images
Immunohistochemistry analysis of paraffin-embedded mouse pituitary using CHST8 (GB113134) at dilution of 1: 3000 | |
Immunohistochemistry analysis of paraffin-embedded rat pituitary using CHST8 (GB113134) at dilution of 1: 3000 |
Storage
Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |