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Anti-CIITA Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CIITA rabbit polyclonal |
Gene Name: | MHC class II transactivator |
Synonyms: | CIITA, C2ta, Mhc2ta, Class II transactivator, NLR family acid domain containing |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse CIITA |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 1000-1: 2000 | spleen, thymus |
Background
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion.
Images
| Immunohistochemistry analysis of paraffin-embedded mouse spleen using CIITA (GB112521) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin-embedded mouse thymus using CIITA (GB112521) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
