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Anti-CITED2 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CITED2 rabbit polyclonal antibody |
Gene Name: | Cbp/p300-interacting transactivator 2 |
Synonyms: | MSG-related protein 1, MRG-1, P35srj, Mrg1, Cited2, Msg2 |
Immunogen: | Recombinant protein corresponding to Mouse CITED2 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 28 kDa |
Observed MW. | 28 kDa |
Uniprot ID: | O35740, Q99MA1 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | brain, heart |
Background
CITED2, also named as P35srj, is a cAMP-responsive element-binding protein (CBP)/p300-transactivator, with an ED(Glu/Asp)-rich C-terminal domain that acts as an important modulator in the development of the heart .It is proposed to be a negative regulator of HIF-1α through its competitive binding to the CH1 domain of CBP/p300, which mediated signaling and to a decrease in HIF-1-responsive genes such as VEGF. In addition, it is also a co-activator of the transcriptional activity of the TFAP2 isoform, which is an extensively expressed nuclear protein with functions in embryogenesis, inflammation, and stress responses.
Images
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Western blot analysis of CITED2 (GB111129) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |