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| Reactivity: | H,M,R & M,R & M,R |
| Applications: | WB & IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CSN8 rabbit polyclonal |
Gene Name: | COP9 signalosome complex subunit 8 |
Synonyms: | SGN8, Signalosome subunit 8, COP9 homolog, JAB1-containing signalosome subunit 8, Cops8, Csn8 |
Immunogen: | Recombinant protein corresponding to Mouse CSN8 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Predicted MW. | 23 kDa |
Observed MW. | 23 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 2000-1: 4000 | heart, brain, testis |
IHC | Mouse, Rat | 1: 2100-1: 4200 | prefrontal lobe, heart |
IF | Mouse, Rat | 1: 500-1: 1000 | hippocampus |
Background
COPS8 is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases.
Images
| Western blot analysis of CSN8 (GB112799) at dilution of 1: 4000 Lane 1: HepG2 cell lysate Lane 2: SH-SY5Y cell lysate Lane 3: U251 cell lysate Lane 4: Mouse heart tissue lysate Lane 5: Mouse brain tissue lysate Lane 6: Mouse testis tissue lysate Lane 7: Rat heart tissue lysate Lane 8: Rat brain tissue lysate Lane 9: Rat testis tissue lysate |
| Immunohistochemistry analysis of paraffin-embedded mouse prefrontal lobe using CSN8 (GB112799) at dilution of 1: 4200 |
| Immunohistochemistry analysis of paraffin-embedded mouse heart using CSN8 (GB112799) at dilution of 1: 4200 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse hippocampus using CSN8 (GB112799) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
