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Anti-CTRP12 Rabbit pAb (100 μl)
| Reactivity: | M,R & H,M,R & M |
| Applications: | WB & IHC/IF & ICC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Adipolin |
Synonyms: | Adipose derived insulin sensitizing factor, C1q domain containing 2, C1q/TNF related protein 12, C1QDC2, C1QTNF12, Fam132a, Protein FAM132A |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse CTRP12 |
Uniprot ID: | Q8R2Z0 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted |
Predicted MW. / Observed MW. | 33 kDa / 33 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 300-1: 500 | adipose tissue |
IHC/IF | Human, Mouse, Rat | 1: 500-1: 1500 | colon cancer, testis, esophagus |
ICC/IF | Mouse | 1: 100-1: 400 | NIH-3T3 |
Background
Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue.; [Adipolin fC1QTNF12]: Acts by activating the Akt signaling in hepatocytes and adipocytes. Not able to increase insulin-stimulated glucose uptake in adipocytes.; [Adipolin gC1QTNF12]: Acts by activating the MAP kinase. Increases insulin-stimulated glucose uptake in adipocytes.
Images
| Western blot analysis of FAM132A (GB114882) at dilution of 1:500 |
| Immunohistochemistry of paraffin embedded human colon cancer using FAM132A (GB114882) at dilution of 1: 600 |
| Immunohistochemistry of paraffin embedded rat testis using FAM132A (GB114882) at dilution of 1: 600 |
| Immunohistochemistry of paraffin embedded mouse testis using FAM132A (GB114882) at dilution of 1: 600 |
| Immunohistochemistry of paraffin embedded mouse esophagus using FAM132A (GB114882) at dilution of 1: 600 |
| Immunocytochemistry analysis of 4% paraformaldehyde-fixed NIH-3T3 cells using FAM132A (GB114882) at dilution of 1: 150 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
