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-23%
Anti-Caspase-3 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Caspase-3 |
Synonyms: | Casp3, CASP3, CPP32, CPP32B, SCA-1, Caspase 3 |
Immunogen: | Recombinant protein corresponding to Mouse Caspase-3 |
Uniprot ID: | P70677 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 32 kDa / 35/17 kDa |
Images
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | liver, lung, brain |
Background
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.
Images
| Western blot analysis of Caspase3 (GB11767C) at dilution of 1: 500 |
| Western blot analysis of Caspase3 (GB11767C) at dilution of 1: 500 |
Storage
| Storage | Store at -20 °C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
